Topic #1 – Breaking the Bottleneck: Advances in Chromatography to Accelerate Biomanufacturing
Advances in upstream processing have increased protein yields per unit volume coming from bioreactors. Unfortunately, the capacity of bioprocessing operations designed years ago may struggle to accommodate the protein titers that can be produced today. Antibody expression levels now routinely exceed 1 g/L whereas levels of 100 mg/L were commonplace in the not so distant past. Successful efforts to maximize bioreactor titer levels have put significant pressure on downstream processes, shifting production bottlenecks from upstream to downstream unit operations.
Our experts describe how the latest advances in chromatography are helping to overcome production bottlenecks.
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