Topic #6: Platform Technologies

Historically, development of protein therapeutics relied on a customized approach for each new molecule. Early efforts focused on establishment of a fixed process that delivered the required quality. Unfortunately, this approach limited application of continuous improvement and incorporation of new technologies to enable improvements in safety and efficacy. In an effort to address this, platform technologies, ...

Within our organization, platform technologies are well established in a number of areas including purification of recombinant proteins, crystallisation of proteins, and for X-ray crystallography. The platforms which we are currently using were developed during the past ten years by numerous experiments and by continuous optimization. Additional knowledge is continuously integrated in the platform ...

The concept of platform technologies started in the industry with the belief that one could purify all monoclonal antibodies the same sequence of technologies: Protein A, cation exchange and then anion exchange. While this is true, what remains to be defined for each new molecule are the specific parameters for each unit, type of ...

We are using platform technologies mainly for the purification of recombinant antibodies from mammalian cell culture. In developing the initial platform, we conducted a research project. Up to now we evaluated several different antibodies from CHO or hybridoma cell cultures. The biggest difference we saw was besides the characteristics of the different subclasses, ...

Historically, development of protein therapeutics relied on a customized approach for each new molecule. Early efforts focused on establishment of a fixed process that delivered the required quality. Unfortunately, this approach limited application of continuous improvement and incorporation of new technologies to enable improvements in safety and efficacy. In an effort to address this, platform technologies, in which prior ...